In clause nine of the general policies of cultural, scientific and technological visions of the Islamic Republic of Iran in 2025 emphasis on organizing and resources and capacities mobilizing in the country in order to increase the country's share of world academic production, so the enthusiasm of managers at universities and higher education institutes is in improving their processes and implementing knowledge management. Accordingly, the aim of this study is to identify the key factors for implementing knowledge management and presenting a model of knowledge management in the universities. To achieve the first objective (identifying the key factors), we use qualitative methods and a structural/interpretative modeling technique to present knowledge management model. Data have been gathered by interview of 25 people of academic experts with academic activities such as articles, books and knowledge management projects. After analyzing data have been summarized into eleven key variables and 162 important issues. The result of this study is to create a model of six components of affecting that as result, strategy and goals of the organization, culture and external environment have the highest impact on the implementation of knowledge management was determined as a component effectiveness. Between the second and fifth level of model consists of five components, structure, capital, knowledge, leadership and management, financial resources, education and technology, human resources as factors and their effects on knowledge management at the University.